Animal Models of Graves' Hyperthyroidism

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Animal models of Graves' disease.

Graves' disease (GD) is an autoimmune condition in which goitre and hyperthyroidism are induced by thyroid stimulating antibodies (TSAB) which mimic the action of thyrotrophin (TSH). The target of the autoimmune response is the thyrotrophin receptor (TSHR) and, since its cloning, a number of differing approaches have been adopted in an attempt to develop an animal model of GD. Methods in which ...

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ژورنال

عنوان ژورنال: Endocrine Journal

سال: 2005

ISSN: 0918-8959,1348-4540

DOI: 10.1507/endocrj.52.385